What is the primary product of methanol metabolism by the ADH and ALDH system?

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Multiple Choice

What is the primary product of methanol metabolism by the ADH and ALDH system?

Explanation:
Methanol is processed by alcohol dehydrogenase to formaldehyde, and then aldehyde dehydrogenase oxidizes that to formic acid. The end product produced by this ADH/ALDH sequence is formic acid, which is the toxic metabolite driving the clinical effects of methanol poisoning. Acetaldehyde is from ethanol metabolism, acetone appears in other metabolic states, and oxalic acid is linked to ethylene glycol metabolism, not methanol.

Methanol is processed by alcohol dehydrogenase to formaldehyde, and then aldehyde dehydrogenase oxidizes that to formic acid. The end product produced by this ADH/ALDH sequence is formic acid, which is the toxic metabolite driving the clinical effects of methanol poisoning. Acetaldehyde is from ethanol metabolism, acetone appears in other metabolic states, and oxalic acid is linked to ethylene glycol metabolism, not methanol.

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